Grant Proposal Guidelines
Request for Application (RFA) for March 1, 2013 and September 1, 2013
Seed funding is now available for innovative proposals that seek to identify and validate biomarkers of A-T disease progression and that can be used to monitor therapeutic efficacy in clinical trials.
Please note that investigator-initiated proposals are also welcome for the March 1 and September 1 grant submission deadlines; however priority will be given to proposals that address the above referenced RFA.
We welcome investigators to contact Cynthia Rothblum-Oviatt, PhD, our Science Coordinator, if help is needed forming collaborations and/or obtaining reagents for A-T/ATM research.
Cynthia Rothblum-Oviatt, PhD
A-T Children's Project
5300 W. Hillsboro Blvd., Suite 105
Coconut Creek, FL 33073
The A-T Children's Project strives to assist respected scientists in developing a clearer understanding of ataxia-telangiectasia. We are determined to find a timely cure, or life-improving treatments, for this serious disease. Grant awards are made through a careful and detailed selection process. The members of our Scientific Advisory Board examine each proposal and make their independent recommendations to our Board of Directors which then votes on each proposed project. Proposals from junior investigators, from scientists in related disciplines, and from individuals with innovative new ideas for A-T research are particularly encouraged, as are laboratories and teams working together from industry as well as teaching universities.
The Project provides competitive grant awards for basic and translational research grants related to A-T. One- and two-year projects are funded up to a maximum total direct cost of US$75,000 per year. Grants of US$75,000 per year, however, are rare; grants in the US$25,000 - 50,000 per year range are much more common.
Applicants please note that unless specific Requests for Applications are present, the A-T Children's Project is currently focusing its funding efforts on:
- translational (bench to bedside) research
- clinical studies
- proposals that apply innovative and novel strategies for suggesting, developing and evaluating specific disease-modifying and symptomatic interventions
As such, these types of applications will be given priority funding.
Applicants should also be aware that meritorious proposals may be rejected if:
- The proposed research is too far from being relevant to a therapeutic intervention
- Our Scientific Advisory Board finds the research redundant and in no need of validation
- The proposed research is likely to happen anyway, without our support
- The research cannot realistically be achieved with the proposed budget
Letters of Intent
A Letter of Intent is not required. However, prior to submission of a full-length proposal, applicants seeking Scientific Advisory Board input may submit a Letter of Intent directly to the A-TCP Science Coordinator at
. This letter (not to exceed two pages) should include a brief abstract describing the proposed research, specific aims and an estimated budget.
Proposal Submission Information and Deadlines
Applicants must submit an electronic copy of their Proposal in either MSWord or PDF formats to
Submission deadlines for grant applications are September 1 and March 1 of each year (or the following business day if the deadline falls on a weekend or holiday).
Grants are reviewed and awarded quickly compared to most other grant-giving organizations. In most cases, a grant decision will be made and communicated to the applicant within 90 days after the grant application deadline.
A. Each application should be no more than ten pages (not including attached articles and CVs), but should have the quality of an NIH proposal.
B. Budgets for up to US$150,000 for a two-year project are acceptable. We do not pay for administrative overhead and indirect costs. We do not pay for institutional construction or renovation; purchase of major capital equipment other than directly needed for proposed experiments; office equipment or furniture; travel (except as required to perform the project); tuition fees; journal subscriptions; dues or memberships; printing or publishing costs.
C. All applicants funded will be required to provide six-month progress reports, as well as annual and final progress reports. These reports must be accompanied by signed financial statements (forms will be provided.)
D. The following order and instructions should be followed in detail:
- Title of research project
- Name, address, telephone number, fax number and e-mail address of principal investigator responsible for project
- Total funds requested for grant
- Name, title, address, telephone number, fax number and email address of institution's grants administrative officer
- Name, title, address, telephone number, fax number and email address of institution's financial officer who is responsible for reports of expenditures and proposed grant funds
- Indicate to whom (and where) grant payment checks should be paid
- Proposed grant period (one year or two years)
- Name, address and telephone number of the institution and/or performance sites where research will be conducted
- Abstract of project: Describe briefly and clearly the nature, objectives, methods of procedure and significance to A-T of the proposed research project.
- Summary for lay persons: Rewrite the abstract in abbreviated form and in terms suitable for presentation to lay persons (200 word limit). Note that this summary should clearly explain the proposed work to non-scientists, but will not necessarily be presented to individuals with any emotional connection to A-T. Therefore, there is no need to interject hoped for but unrealistic long-term results or references to "potential therapies" in an attempt to "sell" the grant.
- Body of proposal (begin on separate page - does not include references) and limited to ten pages
b. Hypothesis and specific aims.
c. Background (previous work by other investigators and applicant).
d. Rationale for current proposal.
e. Methods and procedures.
f. Anticipated problems and limitations.
- Detailed budget (begin on separate page).
Other financial support of principal and co-investigators.
- Description of scientific environment.
- Names, titles, telephone numbers of co-investigators.
- Letters of agreement of co-investigators.
- Curriculum Vitae for investigator and co-investigators (include recent, relevant publications).
- If human subjects will be used in the proposed research, include copies of IRB approval, consent forms and statement of "compliance with government requirements."
- If animals will be used in the proposed research, provide a statement of compliance with American Veterinary Medicine Association and NIH guidelines.