Is the A-T Protein Doing Something Outside of the Nucleus?
2009 - For years, scientists have known that the protein missing in children with A-T, known as ATM, is found in the nucleus of our cells. But researchers have always been curious about whether ATM also plays a role in the cell’s cytoplasm, outside of the nucleus, especially in brain cells that are so negatively impacted by A-T. More »
The Search for Novel Biomarkers for A-T
2009 - An investigator from Indiana, Mu Wang, PhD, from the Indiana University School of Medicine and Monarch Life Sciences, LLC, will be examining spinal fluid in up to twenty patients with A-T to identify proteins that can be used as biomarkers to monitor the progression of this disease and assess the effectiveness of drugs in clinical trials. More »
Could Growth Factors Help Treat A-T?
2009 - To determine if growth factors (GFs) could be a potential life-improving therapy for patients with ataxia-telangiectasia (A‑T), Ralf Schubert, PhD from the Klinikum der Johann Wolfgang Goethe Universitaet in Frankfurt Germany will explore the benefits and risks associated with GF treatment in A-T mice. More »
Astrocytes: Another Type of Brain Cell Involved in A-T?
2009 - Research into how the loss of the A-T protein (called ATM) affects a special type of brain cell known as the astrocyte may help explain the brain deterioration seen in A-T and may point to therapeutic options for this disease. To explore this possibility, the A-T Children’s Project is funding Paul Wong, PhD from The University of Texas MD Anderson Cancer Center. More »
Lung and Swallowing Studies in Chicago, IL and Orlando, FL
2009 - Thanks to the people with A-T who participated in recent lung function studies, doctors may understand why some have more lung problems than others. More »